Nitric oxide, nitrates and ischaemic preconditioning

Nitric oxide, nitrates and ischaemic preconditioning.

1. Introduction model produced significant protection against myocardial cell death. There appears to be a bimodal distribution of In 1986 Furchgott first suggested that endothelial-de-protection with an initial more powerful but short-lived rived relaxing factor might be nitric oxide (NO) [1]. Since phase existing between 1 and 3 h ('Early Preconditioning') then the remarkable role of nitric o...

Inorganic and Organic Nitrates as Sources of Nitric Oxide

Nitric oxide: a trigger for classic preconditioning?

To determine whether nitric oxide (NO) is involved in classic preconditioning (PC), the effect of NO donors as well as inhibition of the L-arginine-NO-cGMP pathway were evaluated on 1) the functional recovery during reperfusion of ischemic rat hearts and 2) cyclic nucleotides during both the PC protocol and sustained ischemia. Tissue cyclic nucleotides were manipulated with NO donors [S-nitroso...

Nitrate esters as nitric oxide donors: SS-nitrates.

[structure: see text]. The important biological secondary messenger NO can be generated from exogenous nitrovasodilators and NO donors. Nitrate esters are nitrovasodilators and NO mimetics, believed to be biotransformed to NO in vivo. On the basis of a mechanistic hypothesis, nitrates have been synthesized that release NO at significant rates in neutral aqueous solution in the presence only of ...

Role of morphine preconditioning and nitric oxide following brain ischemia reperfusion injury in mice

Objective(s): Morphine dependence (MD) potently protects heart against ischemia reperfusion (IR) injury through specific signaling mechanisms, which are different from the pathways involved in acute morphine treatment or classical preconditioning. Since opioid receptor density changes post cerebral ischemia strongly correlated with brain histological damage, in the present study, we tried to el...